Author

A. Gough

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

D. L. Taylor· 3 shared A. M. Stern· 2 shared A. Soto-Gutierrez· 2 shared C. Reese· 2 shared G. LaRocca· 2 shared J. Behari· 2 shared L. Vernetti· 2 shared M. E. Schurdak· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

D. L. Taylor

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A metabolic-dysfunction associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

J. Aleman, R. K, C. Wiegand, M. E. Schurdak, L. Vernetti, D. Gavlock, C. Reese, R. DeBiasio, G. LaRocca, Y. D. Angarita, A. Gough, A. Soto-Gutierrez, J. Behari, V. Yechoor, M. T. Miedel, , D. L. Taylor

This paper develops a coupled microphysiological system to study how liver dysfunction affects pancreatic islet function, finding altered secretomes and glucose responses under metabolic syndrome conditions.

bioRxiv · Apr 22, 2024Bioengineering

Comparison of Wild-Type and High-risk PNPLA3 variants in a Human Biomimetic Liver Microphysiology System for Metabolic Dysfunction-associated Steatotic Liver Disease Precision Therapy

M. Xia, M. Varmazyad, I. P. Palacin, D. C. Gavlock, R. Debiasio, G. LaRocca, C. Reese, R. Florentino, L. A. P. Faccioli, J. A. Brown, L. A. Vernetti, M. E. Schurdak, A. M. Stern, A. Gough, J. Behari, , M. Miedel

This study uses a human liver microphysiology system to compare the effects of PNPLA3 variants on MASLD progression and drug response.

bioRxiv · Apr 22, 2024Cell Biology

Applications of the Microphysiology Systems Database for Experimental ADME-Tox and Disease Models

M. Schurdak, L. Vernetti, L. Bergenthal, Q. K. Wolter, T. Y. Shun, S. Karcher, D. L. Taylor, A. Gough

The paper introduces a database for managing and analyzing microphysiological systems data, demonstrating its use in drug development and disease modeling.

bioRxiv · Sep 25, 2019Pharmacology & Toxicology