Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model
S. S. Qin, B. J. Han, A. Williams, K. M. Jackson, R. Jewell, A. C. Chacon, E. M. Lord, D. C. Linehan, M. Kim, A. Reuben, S. A. A. Gerber, P. A. Prieto
This study develops a murine model of synchronous melanoma to show that genetic differences between tumors create distinct immune microenvironments affecting immunotherapy response.
bioRxiv · Aug 18, 2020Cancer Biology