Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer
A. L. Hughson, G. Hannon, N. A. Salama, T. G. Vrooman, C. A. Stockwell, B. N. Mills, J. Garrett-Larsen, H. Qui, R. Katerji, L. Benoodt, C. J. Johnston, J. D. Murphy, E. Kruger, J. Ye, N. W. Gavras, , S. A. Gerber
This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.
bioRxiv · Oct 30, 2023 · PreprintCancer Biology