Author

D. D. Oprian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

I. J. Krauss· 2 shared J. O. Matos· 2 shared M. Patterson· 2 shared A. C. Ma· 1 shared B. Y. Black· 1 shared D. Theobald· 1 shared E. Oancea· 1 shared J. A. Gehtman· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

I. J. Krauss

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3 papers

Recent·Most cited

Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction

P. K. Ramasamy, J. O. Matos, B. Y. Black, W. H. Ellenburg, J. Chen, M. Patterson, J. A. Gehtman, D. Theobald, I. J. Krauss, D. D. Oprian

The paper solves the crystal structure of caryolan-1-ol synthase with and without a substrate analog, revealing structural changes that suggest a mechanism for anti-Markovnikov cyclization.

bioRxiv · May 4, 2024Biochemistry

Mechanism Underlying Anti-Markovnikov Addition in the Reaction of Pentalenene Synthase

J. O. Matos, R. P. Kumar, A. C. Ma, M. Patterson, I. J. Krauss, D. D. Oprian

The paper elucidates the mechanism of anti-Markovnikov addition in pentalenene synthase by solving crystal structures and showing how residue F76 stabilizes the carbocation through cation-π interactions.

bioRxiv · Jun 17, 2020Biochemistry

The human non-visual opsin OPN3 regulates pigmentation of epidermal melanocytes through interaction with MC1R

R. N. Ozdeslik, L. E. Olinski, M. M. Trieu, D. D. Oprian, E. Oancea

This study identifies OPN3 as a negative regulator of melanin production in human epidermal melanocytes through interaction with MC1R, revealing a light-independent function for OPN3.

bioRxiv · Feb 18, 2019 · PreprintPhysiology