The lysosomal chloride-proton exchanger CLC7 functions in melanosomes as a negative regulator of human pigmentation
D. C. Koroma, J. L. Scales, J. C. Trotman, K. Wakamatsu, S. Ito, E. Oancea
The paper shows CLC7/OSTM1 acidifies melanosomes and negatively regulates pigmentation, with OCA2 counteracting CLC7 mutations.
bioRxiv · Feb 5, 2021 · PreprintCell Biology