Author

D. D. Richardson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Letarte· 2 shared X. Li· 2 shared B. A. Patel· 1 shared C. A. Strulson· 1 shared E. C. Sherer· 1 shared J. A. Pavon· 1 shared J. Liao· 1 shared K. Martinez-Fonts· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

S. Letarte

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2 papers

Recent·Most cited

Qualification of Identity, Quality-Attribute Monitoring and New Peak Detection in An Improved Multi-Attribute Method with Lys-C Digestion for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

X. Li, N. A. Pierson, X. Hua, B. A. Patel, M. H. Olma, C. A. Strulson, S. Letarte, D. D. Richardson

This paper qualifies an improved multi-attribute method (MAM) for mAb identity, quality attributes, and new peak detection using Lys-C digestion and high-resolution MS.

bioRxiv · May 1, 2022 · PreprintBiochemistry

Identification and Characterization of a Residual Host Cell Protein Hexosaminidase B Associated with N-glycan Degradation During the Stability Study of a Therapeutic Recombinant Monoclonal Antibody Product

X. Li, Y. An, J. Liao, L. Xiao, M. Swanson, K. Martinez-Fonts, J. A. Pavon, E. C. Sherer, V. Jawa, X. Gao, S. Letarte, D. D. Richardson

The paper identifies Hexosaminidase B as a residual host cell protein causing N-glycan degradation in a monoclonal antibody under stability conditions and develops strategies to mitigate its impact.

bioRxiv · Sep 17, 2020Biochemistry