X. Hua

Varroa mites escape the evolutionary trap of haplodiploidy

The paper investigates Varroa mites' reproductive system, finding they are not haplodiploid, which helps maintain genetic diversity and adaptability despite invasive challenges.

Novel mRNA vaccines encoding Monkeypox virus M1R and A35R protect mice from a lethal virus challenge

This paper develops mRNA vaccines against Monkeypox virus that protect mice from lethal infection, with fusion protein vaccines showing better immune responses than separate protein vaccines.

Phospholipase C6 Regulates Hydroxyproline O-arabinosyltransferase-mediated Pollen Tube Growth in Arabidopsis

This paper shows that a missense mutation in PLC6 rescues pollen tube growth defects in hpat1/3 mutants, suggesting PLC6 influences polarized growth and HPAT-mediated fertility in Arabidopsis.

Pharmacologic Inhibition of DYRK1A Results in MYC Hyperactivation and ERK Hyperphosphorylation rendering KMT2A-R ALL Cells Sensitive to BCL2 Inhibition

This study shows that inhibiting DYRK1A in KMT2A-R ALL cells leads to MYC upregulation and ERK hyperphosphorylation, making them sensitive to BCL2 inhibition.

From motor protein to toxin: Mutations in the zonula occludens toxin (Zot) of Vibrio cholerae phage CTXΦ suggest a loss of phage assembly function

The paper investigates mutations in the Zot toxin of Vibrio cholerae phage CTXΦ, showing that these mutations impair phage assembly and suggest a shift in Zot's function to an auxiliary toxin.

Qualification of Identity, Quality-Attribute Monitoring and New Peak Detection in An Improved Multi-Attribute Method with Lys-C Digestion for Characterization and Quality Control of Therapeutic Monoclonal Antibodies

This paper qualifies an improved multi-attribute method (MAM) for mAb identity, quality attributes, and new peak detection using Lys-C digestion and high-resolution MS.

GR13-type plasmids in Acinetobacter potentiate the accumulation and horizontal transfer of diverse accessory genes

This study characterizes GR13 plasmids in Acinetobacter, showing their capacity to accumulate and horizontally transfer diverse accessory genes through dif modules and insertion sequences.

Evaluation of the anti-tumor activities of Sulfonylurea Derivatives

This study evaluates the anti-tumor activities of 25 sulfonylurea derivatives in breast carcinoma cell lines, finding concentration- and time-dependent inhibitory effects on cell growth, proliferation, migration, and survival.

Phage Resistance Mechanisms Increase Colistin Sensitivity in Acinetobacter baumannii

This study shows that phage resistance mechanisms in A. baumannii reduce colistin resistance by altering bacterial envelope structure, increasing antibiotic sensitivity.

Protracted speciation under the state-dependent speciation and extinction approach

The paper introduces a model to infer speciation processes from lineage-level trees and tests it on simulated and real data, showing accurate maximum likelihood estimates and patterns consistent with observations.

Investigating the reliability of molecular estimates of evolutionary time when substitution rates and speciation rates vary

This study evaluates molecular dating methods under realistic models of rate variation, finding significant errors in divergence time estimates when substitution and speciation rates covary.

Adapting to extremes: reconstructing evolution in response to changing climate over time and space in the diverse Australian plant genus Acacia

This study uses a new method to show Acacia plants evolved greater tolerance to aridity and salinity as Australia became drier, enabling their spread across diverse habitats.

SSR1 is a vital regulator in plant mitochondrial iron-sulfur biosynthesis

This study identifies SSR1 as a chaperone-like protein that enhances HSCA2-ISU1 interaction in the mitochondrial iron-sulfur cluster biosynthesis pathway, essential for plant mitochondrial function.

Coupling Comprehensive Transcriptome-Metabolome Association and Phylogenetic Analysis Speed Dissecion of Polyphyllins Biosynthetic Pathway

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

BacAnt: A Combination Annotation Server for Bacterial DNA Sequences to Identify Antibiotic Resistance Genes, Integrons, and Transposable Elements.

BacAnt is a webserver that simultaneously annotates antibiotic resistance genes, integrons, and transposable elements in bacterial DNA sequences, generating automated genbank files.

Tracking niche change through time: simultaneous inference of ecological niche evolution and estimation of contemporary niches

This paper introduces NEMo, a method that simultaneously infers ecological niche evolution and estimates contemporary niches by modeling adaptation, speciation, and dispersal on phylogenies.

Differential functions of splicing factors in breast-cancer initiation and metastasis

This study identifies splicing factors involved in breast cancer initiation and metastasis, showing their differential roles and interactions with MYC.

The ecological drivers of variation in global language diversity

The paper analyzes global language diversity to determine the ecological factors driving variation, finding climate has a stronger effect than landscape features.

IQGAP3 Overexpression Correlates with Poor Prognosis and Radiation Therapy Resistance in Breast Cancer

This study shows that high IQGAP3 expression in breast cancer is linked to poor prognosis and resistance to radiation therapy.