SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)
C. M. Sevigny, S. Sengupta, Z. Luo, X. Liu, R. Hu, Z. Zhang, L. Jin, D. A. Pearce, D. Demas, A. N. Shajahan-Haq, R. Clarke
This study identifies SLC7A5 (LAT1) as a contributor to endocrine resistance in ER+ breast cancer by showing its role in metabolic reprogramming and growth suppression upon inhibition.
bioRxiv · Feb 21, 2019 · PreprintCancer Biology