Author

R. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Animal Behavior & Cognition· 1 Biochemistry· 1 Cell Biology· 1 Ecology· 1 Paleontology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 7 Organism:human· 6 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

S. J. Howell· 2 shared S. Sengupta· 2 shared A. Adamson· 1 shared A. Beaudet· 1 shared A. E. McKellar· 1 shared A. I. Lamond· 1 shared A. J. Brenes-Murillo· 1 shared A. J. Edney· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 4 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

S. J. Howell

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

S. Cabral, J. Parsons, H. Harrison, T. Kedward, P. Fullwood, K. Spence, D. Lefley, D. Barden, J. Haworth, J. Watson, K. Tsafou, C. Behan, M. J. Dunning, N. Ali, B. Gyorffy, , R. Clarke

The paper identifies osteomodulin as a promoter of breast cancer bone metastasis through CDK1 activation using proteomics and phosphoproteomics analysis of patient-derived tumors.

bioRxiv · Nov 3, 2023 · PreprintCancer Biology

Subtype-specific circadian clock dysregulation modulates breast cancer biology, invasiveness, and prognosis.

J. A. Hammarlund, S.-Y. Li, G. Wu, J.-W. Lian, S. J. Howell, R. Clarke, A. Adamson, C. F. Goncalves, J. B. Hogenesch, Q.-J. A. Meng, R. C. Anafi

This study identifies subtype-specific circadian clock dysregulation in breast cancer, linking it to EMT, invasiveness, and poorer prognosis.

bioRxiv · May 17, 2023 · PreprintCancer Biology

Borrowing ecological theory to infer interactions between sensitive and resistant breast cancer cell populations

Z. Susswein, S. Sengupta, R. Clarke, S. Bansal

The paper uses ecological theory and in-vitro data to infer interactions between resistant and sensitive breast cancer cell populations, finding a net mutualistic interaction and suggesting adaptive treatment strategies.

bioRxiv · Feb 18, 2022 · PreprintCell Biology

A general deep learning model for bird detection in high resolution airborne imagery

B. G. Weinstein, L. Gardner, V. Saccomanno, A. Steinkraus, A. Ortega, K. Brush, G. Yenni, A. E. McKellar, R. Converse, C. Lippitt, A. Wegmann, N. D. Holmes, A. J. Edney, T. Hart, M. J. Jessopp, , S. K. M. Ernest

The paper develops a general deep learning model for bird detection in aerial imagery, achieving high recall and precision with minimal local training.

bioRxiv · Aug 5, 2021Ecology

Feeding Experimentation Device version 3 (FED3): An open-source home-cage compatible device for measuring food intake and operant behavior

B. A. Matikainen-Ankney, T. Earnest, M. Ali, E. Casey, A. Sutton, A. Legaria, K. Barclay, L. Murdaugh, M. Norris, Y.-H. Chang, K. Nguyen, E. Lin, A. Reichenbach, R. Clarke, R. Stark, , A. Kravitz

The paper introduces FED3, an open-source device for measuring food intake and operant behavior in rodents, demonstrating its utility in quantifying intake, meal patterns, and operant learning across multiple institutions.

bioRxiv · Dec 7, 2020 · PreprintAnimal Behavior & Cognition

A dormant sub-population expressing interleukin-1 receptor characterises anti-estrogen resistant ALDH+ breast cancer stem cells

A. Sarmiento-Castro, E. Caamano-Gutierrez, A. Sims, M. I. James, A. Santiago-Gomez, R. Eyre, C. Clark, M. E. Brown, M. D. Brooks, D. F. Hayes, M. S. Wicha, S. J. Howell, R. Clarke, B. M. Simoes

The paper identifies a dormant ALDH+IL1R1+ sub-population in anti-estrogen resistant breast cancer stem cells and links IL1R1 expression to treatment failure.

bioRxiv · Oct 29, 2019Cancer Biology

SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1)

C. M. Sevigny, S. Sengupta, Z. Luo, X. Liu, R. Hu, Z. Zhang, L. Jin, D. A. Pearce, D. Demas, A. N. Shajahan-Haq, R. Clarke

This study identifies SLC7A5 (LAT1) as a contributor to endocrine resistance in ER+ breast cancer by showing its role in metabolic reprogramming and growth suppression upon inhibition.

bioRxiv · Feb 21, 2019 · PreprintCancer Biology

Functional Anatomy, Biomechanical Performance Capabilities and Potential Niche of StW 573: an Australopithecus Skeleton (circa 3.67 Ma) From Sterkfontein Member 2, and its significance for The Last Common Ancestor of the African Apes and for Hominin Origins

R. H. Crompton, J. McClymont, S. K. S. Thorpe, W. I. Sellers, J. Heaton, T. R. Pickering, T. Pataky, D. Stratford, K. Carlson, T. Jashashvili, A. Beaudet, L. Bruxelles, C. Goh, K. Kuman, R. Clarke

This paper analyzes the morphology of StW 573, an Australopithecus skeleton, to infer its functional anatomy, biomechanical capabilities, and potential niche, suggesting it represents a new species and provides insights into hominin origins.

bioRxiv · Nov 29, 2018 · PreprintPaleontology

Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS

T. Ly, A. Whigham, R. Clarke, A. J. Brenes-Murillo, B. Estes, P. Wadsworth, A. I. Lamond

The paper uses PRIMMUS to analyze proteomic changes during cell cycle progression, identifying phosphorylation sites and their roles in mitotic progression.

bioRxiv · Apr 9, 2017Biochemistry