R. Hu

Therapeutic targeting of KRAS mutation-driven tumorigenesis by extracellular vesicles loaded with small interfering RNA

This study demonstrates that extracellular vesicles loaded with KRAS-targeting siRNA can inhibit tumor growth in mouse models, both intratumorally and intravenously.

Targeted LNPs deliver mRNA encoding IL-15 superagonists to balance efficacy and toxicity in cancer therapy

This study uses targeted mRNA-LNPs to deliver IL-15 superagonists, improving anti-tumor efficacy while reducing toxicity compared to existing therapies.

CDC5L surveils cellular stress responses and stress granule formation through transcriptional repression

This study identifies CDC5L as a transcriptional repressor that prevents spontaneous stress granule formation by suppressing PERK-eIF2 signaling.

Estrogen prevents age-dependent beige adipogenesis failure through NAMPT-controlled ER stress pathway

This study shows estrogen prevents age-related failure in beige adipogenesis by controlling ER stress via NAMPT, improving energy expenditure and glucose tolerance in mice.

Harnessing extracellular vesicles for efficient siRNA delivery in vitro and in vivo

This study develops an efficient siRNA delivery system using extracellular vesicles, demonstrating effective gene silencing in vitro and tumor growth inhibition in vivo.

Percutaneous Intramyocardial Septal Cryoablation: A Canine Model with 6 months Follow-up

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission

This paper introduces a pseudovirus-based method to mimic SARS-CoV-2 cell-to-cell fusion and transmission, demonstrating its utility for screening inhibitors and studying variant fusogenic ability.

African swine fever virus I196L is a virulence determinant and its deletant induces robust protection in Domestic pig

This paper deletes the I196L gene from ASFV SY18, resulting in a less virulent recombinant virus that protects pigs against ASFV challenge.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

Repurposing the Memory-promoting Meclofenoxate Hydrochloride as a Treatment for Parkinson's Disease through Integrative Multi-omics analysis

This study identifies meclofenoxate hydrochloride as a potential treatment for Parkinson's disease by improving mitochondrial metabolism and brain function through multi-omics analysis and experimental validation.

Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery

The paper reports structures of Las1-Grc3 complexes and identifies their role in pre-rRNA cleavage during ribosome biosynthesis.

Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy

This study shows that Cdkn2a regulates beige fat maintenance via BECN1-mediated autophagy, with implications for obesity and diabetes treatment.

JGI Plant Gene Atlas: An updateable transcriptome resource to improve structural annotations and functional gene descriptions across the plant kingdom

The paper introduces the JGI Plant Gene Atlas, a resource that improves gene function annotations by analyzing transcript abundance across 18 species and 604 tissues, identifying 64,620 genes with unknown functions.

The Flowering Repressor SVP recruits the TOPLESS co-repressor to control flowering in chrysanthemum and Arabidopsis

This study shows that SVP interacts with TPL to repress flowering by inhibiting FT gene expression in chrysanthemum and Arabidopsis, highlighting a conserved mechanism across species.

Quantitative imaging of intracellular density with ratiometric stimulated Raman scattering microscopy

This paper introduces a technique to measure intracellular density using ratiometric stimulated Raman scattering microscopy and demonstrates its application in different cell types and 3D tumor spheroids.

Homogeneous environmental selection overturns distance-decay relationship of soil prokaryotic community

The paper shows that environmental selection overrides the distance-decay pattern in soil prokaryotic communities across biomes, revealing a U-shape pattern due to homogeneous environmental factors.

Fluorescence-Activated Droplet Sorting of Polyethylene terephthalate-degrading Enzymes

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

Genetic diversity, evolutionary dynamics and pathogenicity of ferret badger rabies virus variants in mainland China, 2008-2018

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

MLL3/MLL4 Histone Methyltranferase Activity Dependent Chromatin Organization at Enhancers during Embryonic Stem Cell Differentiation

This study investigates how MLL3/MLL4 histone methyltransferase activity influences enhancer-promoter contacts and gene activation during mouse embryonic stem cell differentiation.

Discovery and Functional Characterization of Pro-growth Enhancers in Human Cancer Cells

The paper identifies and characterizes pro-growth enhancers in cancer cells using CRISPR screens, finding lineage-specific enhancers associated with poor prognosis and potential therapeutic targets.

Sex Differences in Solute and Water Handling in the Human Kidney: Modeling and Functional Implications

The paper develops sex-specific models of solute and water transport in the human kidney, identifying transport parameter differences between males and females that explain sex-related differences in urine output, blood pressure regulation, and response to ACE inhibitors.

Hsp70 chaperons TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

This study shows Hsp70 chaperones TDP-43 in liquid-like phase, preventing its aggregation and maintaining dynamic nuclear bodies under stress.

Microtubules and Gαo-signaling independently regulate the preferential secretion of newly synthesized insulin granules in pancreatic islet β cells

The paper investigates how microtubules and Gαo-signaling regulate the preferential secretion of newly synthesized insulin granules in β cells, showing that their absence leads to increased secretion of older granules.

TAZ inhibits GR and coordinates hepatic glucose homeostasis in normal physiologic states

This study identifies TAZ as an inhibitor of GR that regulates hepatic glucose homeostasis by modulating gluconeogenic gene promoter binding.

Dynamic structural order of a low complexity domain facilitates assembly of intermediate filaments

The paper shows that low complexity domains in Drosophila Tm1 proteins form labile cross-β interactions, facilitating intermediate filament assembly through dynamic structural transitions.

Pollutants in Hong Kong Soils: Organochlorine Pesticides and Polychlorinated Biphenyls

The paper analyzes organochlorine pesticides and polychlorinated biphenyls in Hong Kong soils, finding DDT and its metabolites more prevalent than PCBs, with some contamination exceeding guidelines.

Impact of immediate cryopreservation on the establishment of patient derived xenografts from head and neck cancer patients.

This study shows that fresh human cancer tissue can be cryopreserved and later implanted to establish PDXs without affecting growth rates or histologic parameters, enabling molecular profiling before implantation.

Arabidopsis ERF4 and MYB52 Transcription Factors Play Antagonistic Roles in Regulating Homogalacturonan De-methylesterification in Seed Coat Mucilage

Activation of Smad 2/3 signaling by low shear stress mediates artery inward remodeling

This study shows that low shear stress activates Smad 2/3 signaling in endothelial cells, leading to inward artery remodeling.

Fibronectin receptor integrin α5β1 regulates assembly of PP2A complexes through PDE4D: modulation of vascular inflammation and atherosclerosis

This study shows that integrin α5β1 regulates PP2A complex assembly via PDE4D5, reducing vascular inflammation and atherosclerosis in mice.