A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
L. B. Alcaraz, A. Mallavialle, T. David, D. Derocq, F. Delolme, C. Dieryckx, F. Boissiere-Michot, J. Simony-Lafontaine, S. Du Manoir, P. Huesgen, C. M. Overall, S. Tartare-Deckert, W. Jacot, T. Chardes, S. Guiu, , E. Liaudet-Coopman
The paper identifies a 9-kDa SPARC fragment released by cathepsin D in TNBC that promotes tumor progression by enhancing cell migration and invasion.
bioRxiv · Oct 22, 2020 · PreprintCancer Biology