GS-967 and Eleclazine Block Sodium Channels in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes
F. Potet, D. E. Egecioglu, P. W. Burridge, A. L. George
This paper investigates the molecular pharmacology of GS-967 and eleclazine on sodium channels in hiPSC-derived cardiomyocytes, finding they exhibit potent use-dependent block and unique effects on slow inactivation.
bioRxiv · May 8, 2020Pharmacology & Toxicology