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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
11 papers
Recent·Most cited
W. Chi, E. E. Corbett, C. H. Thompson, D. Simkin, H. Adil, N. A. Hawkins, N. A. Callow, L. Barse, A. L. George, J. A. Kearney, Evangelos Kiskinis
This study shows that suppressing KCNH1 rescues seizures and developmental issues caused by gain-of-function variants in KCNH1.
bioRxiv · Nov 9, 2026 · PreprintNeuroscience
K. Pilli, T. J. Allan, M. F. Bennett, R. V. Harris, A. L. Schneider, Q. Shen, J. G. Ma, M. S. Hildebrand, E. E. Palmer, A. L. George, S. F. Berkovic, J. I. Vandenberg, I. E. Scheffer, Chai-Ann Ng
This paper uses automated patch-clamp assays to reclassify SCN1A missense variants, changing classifications for 50% of tested variants.
medRxiv · Nov 9, 2026 · PreprintGenetic & Genomic Medicine
M. Hermosilla-Trespaderne, M. X. Hu-Yang, A. Dannoura, A. M. Frey, A. L. George, M. Trost, J. L. Marin-Rubio
This paper uses proteomics to show trilaciclib induces senescence in CML and NSCLC cells by stabilizing CDK4/6 and activating autophagy.
bioRxiv · Mar 12, 2024Cancer Biology
A. L. George, E. Cook, G. C. S. Smith, S. D. Charnock-Jones, S. O'Rahilly, F. Reimann, F. M. Gribble, R. G. Kay
This study profiles the pregnancy plasma proteome using a novel precipitation method, identifying 433 protein groups with tissue-specific associations and changes during gestation.
bioRxiv · Dec 11, 2023 · PreprintBiochemistry
A. L. George, F. R. Sidgwick, J. E. Watt, M. P. Martin, M. Trost, J. L. Marin-Rubio, M. E. Duenas
This study compares DIA-based label-free quantification methods with TMT-DDA for thermal proteome profiling, finding DIA approaches are comparable or better for detecting drug target engagement.
bioRxiv · Feb 15, 2023Biochemistry
G. Kuenze, C. G. Vanoye, M. C. Wilkinson, R. R. Desai, S. Adusumilli, C. R. Sanders, A. L. George, J. Meiler
bioRxiv · May 31, 2022 · PreprintBiophysics
S. Phul, G. Kuenze, C. G. Vanoye, C. R. Sanders, A. L. George, J. Meiler
This paper develops ANN models to predict the functional impact of KCNQ1 variants using biophysical features, outperforming models based solely on evolutionary features.
bioRxiv · Dec 6, 2021Biophysics
H. Huang, L. M. Chamness, C. G. Vanoye, G. Kuenze, J. Meiler, A. L. George, J. P. Schlebach, C. Sanders
The paper investigates whether gain-of-function mutations in KCNQ1 cause super-trafficking of the potassium channel to the plasma membrane, finding increased surface levels and altered channel activity.
bioRxiv · Jul 29, 2020Biophysics
F. Potet, D. E. Egecioglu, P. W. Burridge, A. L. George
This paper investigates the molecular pharmacology of GS-967 and eleclazine on sodium channels in hiPSC-derived cardiomyocytes, finding they exhibit potent use-dependent block and unique effects on slow inactivation.
bioRxiv · May 8, 2020Pharmacology & Toxicology
H.-H. Kuo, X. Gao, J.-M. DeKeyser, K. A. Fetterman, E. A. Pinheiro, C. J. Weddle, H. Fonoudi, M. V. Orman, M. Romero-Tejeda, M. Jouni, M. Blancard, T. Magdy, C. Epting, A. L. George, P. W. Burridge
This paper introduces a cost-effective, open-source hiPSC culture medium (B8) that reduces costs by 97% and allows weekend-free feeding without compromising growth or differentiation.
bioRxiv · Sep 6, 2019Cell Biology
G. Kuenze, A. M. Duran, H. Woods, K. R. Brewer, E. F. McDonald, C. G. Vanoye, A. L. George, C. R. Sanders, J. Meiler
This paper develops and validates structural models of human KCNQ1 potassium channels to understand mutation-induced dysfunction and guide drug design.
bioRxiv · May 24, 2019Biophysics