Positive modulation of cerebellar α6GABAA receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice
Y.-H. Huang, M. T. Lee, W. Sieghart, D. E. Knutson, L. R. Wimmer, D. Sharmin, J. Cook, M. D. Mihovilovic, L.-C. Chiou
This study evaluates 6GABAAR-selective PAMs for treating essential tremor in harmaline-treated mice, finding they reduce tremor and restore burrowing activity.
bioRxiv · Apr 19, 2021 · PreprintPharmacology & Toxicology