Author

D. Sharmin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. M. Cook· 2 shared A. M. Bernardo· 1 shared A. Y. Fedorov· 1 shared D. E. Knutson· 1 shared E. Sibille· 1 shared H. A. Green· 1 shared J. B. Belayet· 1 shared J. Cook· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersPharmacology & Toxicology

J. M. Cook

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3 papers

Recent·Most cited

Development of non-sedating antischistosomal benzodiazepines

M. Y. Mian, D. Sharmin, P. Mondal, J. B. Belayet, M. M. Hossain, P. McCusker, K. T. Ryan, A. Y. Fedorov, H. A. Green, S. S. Ericksen, M. Zamanian, V. V. N. Phani Babu Tiruveedhula, J. M. Cook, J. D. Chan

This paper develops non-sedating antischistosomal benzodiazepines by modifying meclonazepam's structure, identifying compounds effective in vivo with reduced sedation.

bioRxiv · Jan 26, 2024 · PreprintPharmacology & Toxicology

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a beta-amyloid deposition model of Alzheimer's disease pathology

A. M. Bernardo, M. Marcotte, K. Wong, D. Sharmin, K. P. Pandey, J. M. Cook, E. Sibille, T. D. Prevot

This study shows that GL-II-73, a 5-GABAAR positive allosteric modulator, improves cognitive function and neuronal structure in Alzheimer's disease models despite beta-amyloid accumulation.

bioRxiv · Sep 30, 2022 · PreprintPharmacology & Toxicology

Positive modulation of cerebellar α6GABAA receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice

Y.-H. Huang, M. T. Lee, W. Sieghart, D. E. Knutson, L. R. Wimmer, D. Sharmin, J. Cook, M. D. Mihovilovic, L.-C. Chiou

This study evaluates 6GABAAR-selective PAMs for treating essential tremor in harmaline-treated mice, finding they reduce tremor and restore burrowing activity.

bioRxiv · Apr 19, 2021 · PreprintPharmacology & Toxicology