Author

Y.-H. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1 Ecology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

L. Zhang· 2 shared A. C. Daquinag· 1 shared A. G. Guzman· 1 shared A. G. Robertson· 1 shared A. Gandhi· 1 shared A. Iavarone· 1 shared A. J. Dannenberg· 1 shared A. Lasorella· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCancer Biology

L. Zhang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance

F. Li, Y. Wang, I. Hwang, J.-Y. Janng, L. Zhou, Z. Deng, E. Y. Yu, Y. Cai, C. Wu, Z. Han, Y.-H. Huang, X. Huang, L. Zhang, J. Yao, N. Lue, , H. Zheng

The paper identifies KDM2A as a selective vulnerability in ALT-dependent cancers by showing its role in telomere cluster dissolution through SENP6-mediated SUMO deconjugation.

bioRxiv · Feb 10, 2023 · PreprintCancer Biology

Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

A. Tovy, J. M. Reyes, L. Zhang, Y.-H. Huang, C. Rosas, A. C. Daquinag, A. G. Guzman, R. Ramabadran, C.-W. Chen, T. Gu, S. Gupta, L. Ortinau, D. Park, A. R. Cox, R. E. Rau, , M. A. Goodell

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

eLife · May 30, 2022Peer-reviewedCell Biology

Utilisation of Oxford Nanopore sequencing to generate six complete gastropod mitochondrial genomes as part of a biodiversity curriculum

M. De Vivo, H.-H. Lee, Y.-H. Huang, N. Drever, C.-l. Fong, F. M. G. de Mattos, D. Jain, Y.-H. V. Wen, J. K. Mwihaki, T.-Y. Wang, R. J. Machida, J. Wang, B. K. K. Chan, I. J. Tsai

The paper uses Oxford Nanopore sequencing to generate six gastropod mitochondrial genomes as part of a biodiversity curriculum, demonstrating its utility for hands-on genomics training.

bioRxiv · Mar 24, 2022Ecology

Positive modulation of cerebellar α6GABAA receptors for treating essential tremor: a proof-of-concept study in harmaline-treated mice

Y.-H. Huang, M. T. Lee, W. Sieghart, D. E. Knutson, L. R. Wimmer, D. Sharmin, J. Cook, M. D. Mihovilovic, L.-C. Chiou

This study evaluates 6GABAAR-selective PAMs for treating essential tremor in harmaline-treated mice, finding they reduce tremor and restore burrowing activity.

bioRxiv · Apr 19, 2021 · PreprintPharmacology & Toxicology

IFN-{lambda}4 may contribute to HCV persistence by increasing ER stress and enhancing IRF1 signaling

O. O. Onabajo, F. Wang, M.-H. Lee, O. Florez-Vargas, A. Obajemu, M. A. A. Castro, C. Tanikawa, J. Vargas, S.-F. Liao, C. Song, Y.-H. Huang, C.-Y. Shen, A. R. Banday, T. R. O'Brien, Z. Hu, , L. Prokunina-Olsson

This study investigates the association between IFNL4 genetic variants and HCV-related cirrhosis and HCC risk, finding protective effects against cirrhosis and increased HCC risk in specific populations.

bioRxiv · Oct 28, 2020 · PreprintCancer Biology

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

A. Gandhi, Z.-Y. J. SUN, W. M. KIM, Y.-H. Huang, Y. Kondo, D. A. Bonsor, E. J. Sundberg, G. Wagner, V. K. Kuchroo, G. A. Petsko, R. S. Blumberg

This study identifies key residues and structural dynamics governing the monomer-dimer equilibrium of hCEACAM1 using biophysical and structural methods.

bioRxiv · Jul 14, 2020Immunology

Anti-tumor effects of an Id antagonist with no acquired resistance

P. M. Wojnarowicz, M. G. Escalono, Y.-H. Huang, B. Desai, Y. Chin, R. Shah, S. Xu, O. Ouerfelli, R. K. Soni, J. Philip, D. C. Montrose, J. H. Healey, V. K. Rajasekhar, W. A. Garland, L. Norton, , R. Benezra

This study demonstrates that AGX51, an Id antagonist, effectively inhibits tumor growth in multiple cancer models without inducing acquired resistance.

bioRxiv · Jan 6, 2020 · PreprintCancer Biology