D. E. Speiser

NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion

This study identifies NFAT5 as a key driver of CD8 T cell exhaustion in the tumor microenvironment, showing its role in reducing tumor control and its absence improving it.

Increased receptor affinity and reduced recognition by specific antibodies contribute to immune escape of SARS-CoV-2 variant Omicron

This study shows that SARS-CoV-2 Omicron escapes neutralizing antibodies through increased receptor affinity and reduced antibody recognition, while vaccines still provide some neutralization.

Bedside formulation of a personalized multi-neoantigen vaccine against mammary carcinoma

This paper develops a personalized multi-neoantigen vaccine using long peptides linked to virus-like particles, showing improved anti-tumor effects in a murine mammary carcinoma model.

SARS-CoV-2 variant with higher affinity to ACE2 shows reduced sera neutralization susceptibility

This study evaluates how mutations in the SARS-CoV-2 RBD affect ACE2 binding and neutralization by antibodies, finding increased affinity and reduced susceptibility to neutralization.

The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccination

This study shows that CD8 T stem cell-like memory cells emerge early during Yellow Fever vaccination and persist long-term, challenging models where memory cells arise from effector cells.

The C-terminal extension landscape of naturally presented HLA-I ligands

The paper identifies frequent C-terminal extensions in HLA-I ligands across multiple alleles and demonstrates their recognition by CD8+ T cells.

Simultaneous Enumeration Of Cancer And Immune Cell Types From Bulk Tumor Gene Expression Data

The paper presents an algorithm to estimate cancer and immune cell fractions from bulk tumor gene expression data, validated with multiple experimental methods.