Author

W. Held

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. E. Speiser· 2 shared M. Charmoy· 2 shared S. J. Carmona· 2 shared S. Nassiri· 2 shared A. Bovay· 1 shared C. Lopez-Rodriguez· 1 shared D. Cropp· 1 shared D. Gfeller· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

D. E. Speiser

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Induction of mitophagy reverts age-associated decline of the hematopoietic and immune systems

Y.-H. Chiang, M. Charmoy, P. Ginefra, F. Schyrr, F. Franco, P.-C. Ho, O. Naveiras, J. Auwerx, W. Held, N. Vannini

This study shows that inducing mitophagy with Urolithin-A restores hematopoietic and immune system function in aged mice.

bioRxiv · Mar 30, 2023 · PreprintImmunology

NFAT5 induction by the tumor microenvironment enforces CD8 T cell exhaustion

L. Tille, D. Cropp, G. Bodley, M. Andreatta, M. Charmoy, I. Crespo-Casajus, S. Nassiri, J. Lourenco, M. M. Leblond, C. Lopez-Rodriguez, D. E. Speiser, S. J. Carmona, W. Held, G. Verdeil

This study identifies NFAT5 as a key driver of CD8 T cell exhaustion in the tumor microenvironment, showing its role in reducing tumor control and its absence improving it.

bioRxiv · Mar 15, 2022Immunology

The human CD8 T stem cell-like memory phenotype appears in the acute phase in Yellow Fever virus vaccination

S. A. Fuertes Marraco, A. Bovay, S. Nassiri, H. Maby-El Hajjami, H. Ouertatani-Sakouhi, W. Held, D. E. Speiser

This study shows that CD8 T stem cell-like memory cells emerge early during Yellow Fever vaccination and persist long-term, challenging models where memory cells arise from effector cells.

bioRxiv · Oct 17, 2019 · PreprintImmunology

Deciphering the transcriptomic landscape of tumor-infiltrating CD8 lymphocytes in B16 melanoma tumors with single-cell RNA-Seq

S. J. Carmona, I. Siddiqui, M. Bilous, W. Held, D. Gfeller

This study identifies four CD8 TIL states in B16 melanoma tumors using single-cell RNA-seq and finds anti-PD-1 treatment expands EM-like cells.

bioRxiv · Oct 10, 2019Immunology