Author

D. Gagne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

J. M. Aramini· 2 shared K. H. Gardner· 2 shared X. Xu· 2 shared B. A. Johnson· 1 shared E. A. Isiorho· 1 shared J. P. Williams· 1 shared K. Akasaka· 1 shared L. P. Marcelino· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiophysics

J. M. Aramini

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2 papers

Recent·Most cited

Use of High Pressure NMR Spectroscopy to Rapidly Identify Proteins with Internal Ligand-Binding Voids

D. Gagne, R. Azad, J. M. Aramini, X. Xu, E. A. Isiorho, U. R. Edupuganti, J. P. Williams, L. P. Marcelino, B. A. Johnson, K. Akasaka, K. H. Gardner

This paper introduces a method using high-pressure NMR spectroscopy to identify proteins with internal ligand-binding voids by detecting nonlinear chemical shift changes in 1H/15N HSQC experiments.

bioRxiv · Aug 25, 2020 · PreprintBiophysics

High-Pressure NMR Reveals Volume and Compressibility Differences Between Two Stably Folded Protein Conformations

X. Xu, D. Gagne, J. M. Aramini, K. H. Gardner

The paper uses high-pressure NMR to study conformational changes in ARNT PAS-B Y456T, finding that the slipped conformation is smaller and less compressible than the wildtype and involves an unfolded intermediate.

bioRxiv · Jul 29, 2020Biophysics