Author

J. P. Williams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

A. K. Paulson· 1 shared B. A. Johnson· 1 shared B. J. Bennion· 1 shared D. Gagne· 1 shared D. Miyao· 1 shared D. Shi· 1 shared E. A. Isiorho· 1 shared H. L. Osswald· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. K. Paulson

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Author profile →

2 papers

Recent·Most cited

Generative Molecular Design and Experimental Validation of Selective Histamine H1 Inhibitors

K. S. McLoughlin, D. Shi, J. E. Mast, J. Bucci, J. P. Williams, W. D. Jones, D. Miyao, L. Nam, H. L. Osswald, L. Zegelman, J. E. Allen, B. J. Bennion, A. K. Paulson, R. Abagyan, M. S. Head, J. M. Brase

The paper develops a generative molecular design platform, ATOM-GMD, to create selective histamine H1 inhibitors, which are validated experimentally with six compounds showing high potency and selectivity.

bioRxiv · Feb 14, 2023 · PreprintPharmacology & Toxicology

Use of High Pressure NMR Spectroscopy to Rapidly Identify Proteins with Internal Ligand-Binding Voids

D. Gagne, R. Azad, J. M. Aramini, X. Xu, E. A. Isiorho, U. R. Edupuganti, J. P. Williams, L. P. Marcelino, B. A. Johnson, K. Akasaka, K. H. Gardner

This paper introduces a method using high-pressure NMR spectroscopy to identify proteins with internal ligand-binding voids by detecting nonlinear chemical shift changes in 1H/15N HSQC experiments.

bioRxiv · Aug 25, 2020 · PreprintBiophysics