Alpha-synuclein aggregates are phosphatase resistant
S. G. Choi, Tyler Tittle, D. Garcia-Prada, Jeffrey H. Kordower, Ronald Melki, Bryan A. Killinger
This study shows that alpha-synuclein aggregates are resistant to phosphatase dephosphorylation and introduces a method using calf intestinal phosphatase (CIAP) to specifically detect aggregated PSER129 in biological samples.
Acta Neuropathologica Communications · May 31, 2024Peer-reviewedNeuroscience