Jeffrey H. Kordower

The paper investigates whether α-synuclein seeding from host tissue contributes to Lewy pathology in dopaminergic neuron grafts in Parkinson's disease patients.

This study links neuronal population organization disruption to behavioral changes in a macaque model of early-stage Alzheimer's disease and related dementias.

Proximity proteomics in PFF-seeded mouse olfactory bulb shows aggregated phospho-S129 alpha-synuclein mostly reprioritizes existing interactions toward axon-glia, myelin and proteostasis proteins, with a conserved 107-protein signature.

The paper introduces a novel mouse model of Parkinson's disease using a modified viral vector to induce pigmentation and pathological features associated with the disease.

The paper examines alpha-synuclein aggregation and molecular changes in appendix tissues from synucleinopathy patients compared to controls.

This study investigates the role of CD8+ T cells in a mouse model of multiple system atrophy and finds they are not critical for disease progression but modulate neuroinflammation and demyelination.

This study shows that alpha-synuclein aggregates are resistant to phosphatase dephosphorylation and introduces a method using calf intestinal phosphatase (CIAP) to specifically detect aggregated PSER129 in biological samples.

The study tests whether GBA1 mutations or mouse genotype affect alpha-synuclein seeding in mice, finding no significant influence on seeding efficacy or pathology spread.

The paper identifies PSER129 accumulation in healthy olfactory bulb mitral cells and links it to synucleinopathy pathogenesis through protein interactome analysis.

The paper investigates how increased ser31 tyrosine hydroxylase phosphorylation in the substantia nigra compensates for dopamine loss and delays hypokinesia onset in a rat model of Parkinson's disease.

This study shows that IFNγ from CD4+ T cells drives neuroinflammation and demyelination in a mouse model of MSA.

This study characterizes non-human primate dura in health and neurodegeneration, revealing a complex lymphatic system and disease-specific biomarker associations.

This paper develops a method to label, extract, and purify Lewy pathology from formalin-fixed human tissue using biotinylation by antigen recognition, revealing molecular signatures associated with Parkinson's and Dementia with Lewy Bodies.

This study shows that overexpressing Nurr1 in the striatum of rats induces LID and worsens dyskinesia, suggesting Nurr1 as a therapeutic target for Parkinson’s disease.

This study shows that loss of one Engrailed1 allele in mice increases α-synuclein aggregation after PFF injection, suggesting a role for En1 in PD pathology.