Overcoming microenvironment-mediated chemoprotection through stromal Galectin-3 inhibition in acute lymphoblastic leukemia
N. Heisterkamp, S. S. Tarighat, F. Fei, E. j. Joo, H. Abdel-Azim, K. Bum-Erdene, D. Grice, H. Blanchard, M. von Itzstein, H. Geng, L. Yang
This study shows that inhibiting stromal Galectin-3 enhances chemotherapy effectiveness in BCP-ALL by disrupting leukemia cell migration, adhesion, and drug resistance.
bioRxiv · Sep 24, 2021Cancer Biology