Author

N. Heisterkamp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

L. Yang· 3 shared E. j. Joo· 2 shared F. Fei· 2 shared M. Zhang· 2 shared D. Chen· 1 shared D. Grice· 1 shared H. Abdel-Azim· 1 shared H. Blanchard· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

L. Yang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Drug-tolerant persister B-cell precursor acute lymphoblastic leukemia cells

M. Zhang, L. Yang, D. Chen, N. Heisterkamp

The paper identifies genes and pathways contributing to drug-tolerant persistence of B-cell precursor acute lymphoblastic leukemia cells under chemotherapy.

bioRxiv · Feb 28, 2023 · PreprintCancer Biology

Targeting interactions between the Galectin-3 intrinsically disordered and structured domains based on long time-scale accelerated molecular dynamics

S. Bhattacharya, M. Zhang, W. Hu, T. Qi, N. Heisterkamp

This study uses MD simulations and NMR to identify a binding cavity in Galectin-3's CTD that interacts with its disordered NTD, and designs an inhibitory peptide targeting this interface.

bioRxiv · Sep 27, 2021 · PreprintBiochemistry

Overcoming microenvironment-mediated chemoprotection through stromal Galectin-3 inhibition in acute lymphoblastic leukemia

N. Heisterkamp, S. S. Tarighat, F. Fei, E. j. Joo, H. Abdel-Azim, K. Bum-Erdene, D. Grice, H. Blanchard, M. von Itzstein, H. Geng, L. Yang

This study shows that inhibiting stromal Galectin-3 enhances chemotherapy effectiveness in BCP-ALL by disrupting leukemia cell migration, adhesion, and drug resistance.

bioRxiv · Sep 24, 2021Cancer Biology

Cell-Intrinsic and Extrinsic Effects of Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

N. Heisterkamp, E. j. Joo, L. Yang, J. Groffen, F. Fei

This study shows Galectin-1 and Galectin-3 promote BCP-ALL cell growth and survival through intrinsic and extrinsic mechanisms, and their inhibition increases chemotherapy sensitivity.

bioRxiv · Sep 22, 2021 · PreprintCancer Biology