A Small interfering RNA lead targeting RNA-dependent RNA-polymerase effectively inhibit the SARS-CoV-2 infection in Golden Syrian hamster and Rhesus macaque
S. H. Gu, C. H. Yu, Y. Song, N. Y. Kim, E. Sim, J. Y. Choi, D. H. Song, G. H. Hur, Y. K. Shin, S. T. Jeong
The paper screens siRNA molecules to target SARS-CoV-2 and shows that an RdRp-targeting siRNA reduces infection in hamsters and macaques.
bioRxiv · Jul 7, 2020 · PreprintMicrobiology