Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy
M.-H. Lin, P. Maniam, D. Li, B. Tang, C. Bishop, A. Suhrbier, L. Wales-Earl, Y. Tayyar, N. A. J. McMillan, L. Li, D. Harrich
This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.
bioRxiv · Apr 23, 2024Microbiology