A. Suhrbier

TMEM106B-mediated SARS-CoV-2 infection allows for robust ACE2-independent infection in vitro but not in vivo

This study identifies TMEM106B as a key mediator of ACE2-independent SARS-CoV-2 infection in vitro but shows no in vivo neuroinvasiveness or respiratory tract replication in mice.

Harnessing defective interfering particles and lipid nanoparticles for effective delivery of an anti-dengue virus RNA therapy

This paper demonstrates that DI290-loaded lipid nanoparticles (LNP-290) effectively suppress DENV infection in cell cultures and mice, inducing IFN responses and preventing clinical signs.

Tracking inflammation resolution signatures in lungs after SARS-CoV-2 omicron BA.1 infection of K18-hACE2 mice

This study tracks inflammation resolution in lungs of K18-hACE2 mice infected with SARS-CoV-2 omicron BA.1, showing reduced cytokine signatures and increased anti-inflammatory cell types over time.

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

This study shows that microplastics co-delivered with SARS-CoV-2 in mice suppress early innate immune responses but promote a cytokine release syndrome signature later in infection.

Neurovirulence of the Australian outbreak Japanese Encephalitis virus genotype 4 is lower compared to genotypes 2 and 3 in mice and human cortical brain organoids

This study compares the neurovirulence of JEV genotype 4 (JEVNSW/22) with genotypes 2 and 3 in mice and human brain organoids, finding JEVNSW/22 less neurovirulent and more sensitive to type I interferon.

Increased neurovirulence of omicron BA.5 and XBB variants over BA.1 in K18-hACE2 mice and human brain organoids

This study shows that omicron BA.5 and XBB variants are more neurovirulent than BA.1 in mice and human brain organoids, leading to increased brain infection and mortality.

ACE2-independent SARS-CoV-2 infection and mouse adaption emerge after passage in cells expressing human and mouse ACE2

The paper describes the generation of mouse-adapted SARS-CoV-2 variants through serial passaging in co-cultures of human and mouse ACE2-expressing cells, revealing ACE2-independent infection capabilities.

Microplastic consumption induces inflammatory signatures in the colon and prolongs a viral arthritis

This study shows that microplastic consumption in mice causes mild colon inflammation and prolongs viral arthritis by increasing Th1, NK cell, and neutrophil signatures.

Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis

This study identifies how ZIKV sfRNA interacts with NS5 to inhibit STAT1 phosphorylation, promoting viral pathogenesis in placental and neural tissues.

An inconvenient association between granzyme A and Nicotinamide Nucleotide Transhydrogenase

The paper identifies an association between granzyme A and Nicotinamide Nucleotide Transhydrogenase in mice, showing that Nnt, not GzmA loss, affects disease outcomes and highlights inconsistencies in Nnt sequencing data.

ACE2-lentiviral transduction enables mouse SARS-CoV-2 infection and mapping of receptor interactions

This paper develops an ACE2-lentivirus system to enable SARS-CoV-2 infection in mice, showing it can model viral replication, inflammation, and vaccine testing.

An adaptive compromise - Conflicting evolutionary pressures on arthropod borne Zika virus dinucleotide composition in mammalian hosts and mosquito vectors

This study investigates how Zika virus balances CpG suppression in vertebrate hosts with different compositional needs in mosquito vectors, showing that CpG-high mutants replicate better in mosquitoes and show vaccine potential in mice.

Simple rapid in vitro screening method for SARS-CoV-2 anti-virals that identifies potential cytomorbidity-associated false positives

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.

Temperature alters gene expression in mosquitoes during arbovirus infection

This study investigates how temperature affects gene expression in mosquitoes infected with chikungunya virus, finding that 28°C elicits the strongest immune response.

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 By Disrupting The Spike-ACE2 interaction

This paper shows that pixatimod inhibits SARS-CoV-2 by disrupting the Spike-ACE2 interaction, demonstrating its potential as an anti-COVID-19 therapeutic.

Systems Analysis of Subjects Acutely Infected with Chikungunya Virus

This study uses systems biology to analyze blood transcriptomes of CHIKV-infected adults, identifying gene signatures linked to viral RNA and symptoms, and comparing them to dengue and rheumatoid arthritis.