Basal extrusion drives cell invasion and mechanical stripping of E-cadherin
J. Fadul, G. M. Slattum, N. M. Redd, T. F. Zulueta-Coarasa, M. Redd, S. Daetwyler, D. Hedeen, J. Huisken, J. Rosenblatt
This study shows that basal extrusion drives tumor cell invasion and mechanical shedding of E-cadherin in zebrafish epidermis, with KRas mutations increasing invasion rates and p53 mutations enabling survival at distant sites.
bioRxiv · Nov 6, 2018 · PreprintCancer Biology