J. Rosenblatt

Bronchoconstriction damages airway epithelia by excess crowding-induced extrusion

This study shows that bronchoconstriction causes epithelial cell extrusion, leading to airway damage, inflammation, and mucus secretion, and that inhibiting extrusion prevents these symptoms.

Voltage-dependent volume regulation controls epithelial cell extrusion and morphology

The paper shows that cell shrinkage via voltage and water regulation determines which epithelial cells are extruded in crowded conditions.

Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

The paper shows that mechanical confinement drives mesenchymal trans-differentiation of invasive KRasV12-transformed cells in zebrafish, contributing to metastasis.

Piezo1 activates non-canonical EGFR endocytosis and signaling.

This study identifies Piezo1 as a mechanosensor that activates EGFR signaling through serine phosphorylation, distinct from EGF-induced tyrosine phosphorylation, leading to sustained proliferation and potential therapeutic implications.

Automated assessment reveals extinction risk of reptiles is widely underestimated across space and phylogeny

This paper presents an automated machine learning method to assess extinction risk for unassessed reptiles, finding that unassessed species are more likely to be threatened and that assessor bias affects outcomes.

Cell cycle S-phase arrest drives cell extrusion

This study identifies S-phase arrest as an evolutionarily conserved trigger of cell extrusion across species.

Basal extrusion drives cell invasion and mechanical stripping of E-cadherin

This study shows that basal extrusion drives tumor cell invasion and mechanical shedding of E-cadherin in zebrafish epidermis, with KRas mutations increasing invasion rates and p53 mutations enabling survival at distant sites.