Author

D. J. Fear

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Assay:multiome· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Cutrina-Pons· 1 shared A. de Sa· 1 shared C. Lebrero-Fernandez· 1 shared D. D'Cruz· 1 shared F. Ramadani· 1 shared H. Gould· 1 shared J. D. Sanderson· 1 shared J. H. Siu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Cutrina-Pons

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Author profile →

2 papers

Recent·Most cited

Inhibition of PI3K p110δ activity reduces IgE production in IL-4 and anti-CD40 stimulated human tonsil B cell cultures

A. Cutrina-Pons, A. de Sa, D. J. Fear, H. Gould, F. Ramadani

This study shows that inhibiting PI3K p110δ reduces IgE production in human B cells stimulated with IL-4 and anti-CD40, but not IgG1, and identifies proliferation as the key mechanism.

bioRxiv · Aug 9, 2022Immunology

Human marginal zone B cell development from early T2 progenitors

T. J. Tull, M. J. Pitcher, W. Guesdon, J. H. Siu, C. Lebrero-Fernandez, Y. Zhao, N. Petrov, S. Heck, R. Ellis, P. Dhami, U. D. Kadolsky, M. Kleeman, Y. Kamra, D. J. Fear, S. John, , J. Spencer

The paper identifies an IgMhi developmental trajectory in human B cell maturation that connects T2 progenitors to marginal zone B cells and links its disruption to severe SLE.

bioRxiv · Sep 24, 2020Cell Biology