Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
L. Ye, M. Bae, C. D. Cassilly, S. V. Jabba, D. W. Thorpe, A. M. Martin, H.-Y. Lu, J. Wang, J. D. Thompson, C. R. Lickwar, K. D. Poss, D. J. Keating, S.-E. Jordt, J. Clardy, R. A. Liddle, J. F. Rawls
This study identifies a molecular pathway by which enteroendocrine cells respond to bacterial tryptophan catabolites, activating enteric and vagal neurons through Trpa1 signaling.
bioRxiv · Jun 9, 2020Physiology