Author

D. J. Kwiatkowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Assay:proteomics· 1

Frequent Co-Authors

A. K. Perl· 1 shared A. Potter· 1 shared E. J. Kopras· 1 shared E. M. Mrozek· 1 shared E. P. Henske· 1 shared E. Y. Zhang· 1 shared F. X. McCormack· 1 shared I. Malinowska· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

A. K. Perl

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3 papers

Recent·Most cited

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and rewires the microenvironment toward an immune-suppressive state

Y. Tang, D. J. Kwiatkowski, E. P. Henske

This study identifies a stem-like tumor cell state in TSC-associated tumors that drives resistance to mTOR inhibition and promotes an immune-suppressive microenvironment through midkine expression.

bioRxiv · Jun 1, 2022 · PreprintCancer Biology

Identification of Hsp90 inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

E. M. Mrozek, V. Bajaj, Y. Guo, I. Malinowska, J. Zhang, D. J. Kwiatkowski

This study identifies HSP90 inhibitors as potential drugs for TSC1/TSC2 deficient cancer but finds rapamycin is more effective in vivo despite modest in vitro inhibition.

bioRxiv · Feb 26, 2021Cancer Biology

Identification of the lymphangioleiomyomatosis cell and its uterine origin

M. Guo, J. J. Yu, A. K. Perl, K. A. Wikenheiser-Brokamp, M. Riccetti, E. Y. Zhang, P. Sudha, M. Adam, A. Potter, E. J. Kopras, K. Giannikou, S. S. Potter, S. Sherman, S. R. Hammes, D. J. Kwiatkowski, , Y. Xu

This study identifies LAMCORE cells as the source of lymphangioleiomyomatosis, showing their uterine neural crest origin and identifying potential biomarkers and therapeutic targets.

bioRxiv · Oct 8, 2019 · PreprintCancer Biology