Author

F. X. McCormack

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pathology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:mouse· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

E. J. Kopras· 4 shared J. J. Yu· 4 shared E. Y. Zhang· 3 shared M. Guo· 3 shared Y. Xu· 3 shared A. A. Zhang· 2 shared E. P. Smith· 2 shared J. A. Whitsett· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

E. J. Kopras

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis

Y. Hasegawa, J. M. Franks, Y. Tanaka, Y. Uehara, D. F. Read, C. Williams, S. Srivatsan, L. B. Pitstick, N. M. Nikolaidis, C. M. Shaver, H. Wu, J. C. Gardner, A. R. Osterburg, J. J. Yu, E. J. Kopras, , F. X. McCormack

The paper investigates silica-induced pulmonary fibrosis in mice, finding that silica triggers osteoclast-like differentiation of macrophages and monocytes, contributing to lung injury and fibrosis.

bioRxiv · Feb 17, 2023Pathology

Interleukin 31 receptor alpha induces airway hyperresponsiveness in asthma

s. Akkenepally, D. J. Yombo, S. Yerubandi, B. R. Geereddy, F. X. McCormack, S. K. Madala

The paper identifies IL-31RA's role in inducing airway hyperresponsiveness through CHRM3 and calcium signaling in ASMC, independent of inflammation and goblet cell hyperplasia in asthma.

bioRxiv · Dec 15, 2022 · PreprintPathology

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

T. F. Olatoke, A. Wagner, A. A. Astrinidis, M. Guo, E. Y. Zhang, A. A. Zhang, U. Mattam, K. Chilton, E. J. Kopras, N. Gupta, E. P. Smith, M. Karbowniczek, M. M. Markiewski, K. Wikenheiser-Brokamp, J. A. Whitsett, , J. J. Yu

This study identifies PBX1 as a critical regulator of LAM progression by analyzing scRNA-seq data and validating its role in LAM cell survival and lung colonization.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex

A. Astrinidis, C. Li, E. Y. Zhang, X. Zhao, S. Zhao, M. Guo, R. Huang, A. A. Zhang, E. J. Kopras, N. Gupta, E. P. Smith, E. Fugate, D. Lindquist, K. Wikenheiser-Brokamp, K. D. Setchell, , J. J. Yu

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

bioRxiv · Sep 25, 2022 · PreprintCell Biology

Identification of the lymphangioleiomyomatosis cell and its uterine origin

M. Guo, J. J. Yu, A. K. Perl, K. A. Wikenheiser-Brokamp, M. Riccetti, E. Y. Zhang, P. Sudha, M. Adam, A. Potter, E. J. Kopras, K. Giannikou, S. S. Potter, S. Sherman, S. R. Hammes, D. J. Kwiatkowski, , Y. Xu

This study identifies LAMCORE cells as the source of lymphangioleiomyomatosis, showing their uterine neural crest origin and identifying potential biomarkers and therapeutic targets.

bioRxiv · Oct 8, 2019 · PreprintCancer Biology