E. Y. Zhang

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

Combination of Volasertib and Rapamycin Inhibits the Regrowth of TSC2-Deficient Tumors

This study shows that combining volasertib and rapamycin inhibits tumor regrowth in TSC2-deficient models more effectively than rapamycin alone.

Integrative Single Cell Multiomic Profiling Analysis Reveals HOX-PBX Gene Regulatory Network Contributing to the Survival of mTOR Hyperactive Cells

This study identifies PBX1 as a critical regulator of LAM progression by analyzing scRNA-seq data and validating its role in LAM cell survival and lung colonization.

Dysregulation of Acid Ceramidase-mediated Sphingolipid Metabolism Contributes to Tumor Progression in Tuberous Sclerosis Complex

This study identifies dysregulated sphingolipid metabolism in TSC2-null cells and tumors, showing that ASAH1 inhibition reduces cell viability and tumor growth in TSC and LAM.

Downregulation of NCL attenuates tumor formation and growth in cervical cancer by targeting the PI3K/AKT pathway

This study shows that reducing NCL in cervical cancer cells inhibits tumor growth by suppressing the PI3K/AKT pathway and promoting apoptosis.

Identification of the lymphangioleiomyomatosis cell and its uterine origin

This study identifies LAMCORE cells as the source of lymphangioleiomyomatosis, showing their uterine neural crest origin and identifying potential biomarkers and therapeutic targets.