Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer
P. L. Theard, E. Sheffels, N. E. Sealover, A. J. Linke, D. J. Pratico, R. L. Kortum
The paper shows that inhibiting SOS1 synergizes with EGFR-TKIs in 3D spheroids of EGFR-mutated NSCLC, enhancing signaling pathway inhibition.
bioRxiv · Apr 28, 2020Cancer Biology