Author

P. L. Theard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. J. Linke· 3 shared N. E. Sealover· 3 shared R. L. Kortum· 3 shared B. R. Daley· 2 shared D. J. Pratico· 1 shared E. Sheffels· 1 shared J. M. Hughes· 1 shared J. Yang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

A. J. Linke

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3 papers

Recent·Most cited

In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

N. E. Sealover, P. L. Theard, J. M. Hughes, A. J. Linke, B. R. Daley, R. L. Kortum

This paper introduces an in situ resistance assay to model acquired resistance to RTK/RAS pathway targeted therapies and shows SHP2 inhibitors can delay resistance development.

bioRxiv · Jan 27, 2023Cancer Biology

SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

P. L. Theard, A. J. Linke, N. E. Sealover, B. R. Daley, J. Yang, K. Cox, R. L. Kortum

This study shows SOS2 modulates EGFR-PI3K signaling threshold, affecting osimertinib efficacy and resistance in lung adenocarcinoma.

bioRxiv · Jan 20, 2023Cancer Biology

Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer

P. L. Theard, E. Sheffels, N. E. Sealover, A. J. Linke, D. J. Pratico, R. L. Kortum

The paper shows that inhibiting SOS1 synergizes with EGFR-TKIs in 3D spheroids of EGFR-mutated NSCLC, enhancing signaling pathway inhibition.

bioRxiv · Apr 28, 2020Cancer Biology