Author

E. Sheffels

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

N. E. Sealover· 2 shared R. L. Kortum· 2 shared A. Frank· 1 shared A. J. Linke· 1 shared A. Linke· 1 shared B. Mair· 1 shared B. R. Daley· 1 shared C. L. Dalgard· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

N. E. Sealover

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Author profile →

2 papers

Recent·Most cited

SOS1 inhibition enhances the efficacy of and delays resistance to G12C inhibitors in lung adenocarcinoma

B. R. Daley, N. E. Sealover, E. Sheffels, J. M. Hughes, D. Gerlach, M. H. Hofmann, K. Kostyrko, B. Mair, A. Linke, Z. Beckley, A. Frank, C. L. Dalgard, R. L. Kortum

This study shows that SOS1 inhibition with BI-3406 enhances G12C inhibitor efficacy and delays resistance in lung adenocarcinoma by targeting resistance mechanisms and drug-tolerant persister cells.

bioRxiv · Dec 7, 2023 · PreprintCancer Biology

Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer

P. L. Theard, E. Sheffels, N. E. Sealover, A. J. Linke, D. J. Pratico, R. L. Kortum

The paper shows that inhibiting SOS1 synergizes with EGFR-TKIs in 3D spheroids of EGFR-mutated NSCLC, enhancing signaling pathway inhibition.

bioRxiv · Apr 28, 2020Cancer Biology