D. J. Waxman

Steatotic liver disease induced by TCPOBOP-activated hepatic constitutive androstane receptor: Primary and secondary gene responses with links to disease progression

This study investigates TCPOBOP-induced steatotic liver disease in mice, identifying primary and secondary gene responses linked to disease progression and potential biomarkers.

Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury

This study shows that growth hormone treatment accelerates liver recovery in male mice after acetaminophen overdose, outperforming standard-of-care N-acetyl cysteine.

TCDD dysregulation of lncRNA expression, liver zonation and intercellular communication across the liver lobule

This study uses snRNA-seq to analyze TCDD-induced dysregulation of lncRNAs, liver zonation, and intercellular communication in mouse liver.

Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver

This study identifies G23Rik as a PPAR-regulated lncRNA that reduces hepatic lipid accumulation during fasting.

Impact of neonatal activation of nuclear receptor CAR (Nr1i3) on Cyp2 gene expression in adult mouse liver

This study shows neonatal TCPOBOP exposure increases adult hepatic Cyp2 gene expression, but this effect can be explained by residual TCPOBOP, not epigenetic memory.

Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine triple-negative breast cancer

This study shows that type-I interferon signaling is essential for cyclophosphamide-induced tumor regression in mouse TNBC models through chemo-immunogenic mechanisms.

Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver

The paper identifies xenobiotic-responsive long non-coding RNAs (lncRNAs) in rat liver and their regulatory networks related to fatty acid metabolism, cell division, and immune response.