C. Villacorta-Martin

Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury

This study shows that growth hormone treatment accelerates liver recovery in male mice after acetaminophen overdose, outperforming standard-of-care N-acetyl cysteine.

Generation of human alveolar epithelial type I cells from pluripotent stem cells

This study generates human alveolar epithelial type I cells from iPSCs by activating YAP signaling, revealing Hippo-LATS-YAP's role in their differentiation.

Mapping Cellular Response to Destabilized Transthyretin Reveals Cell- and Amyloidogenic Protein-Specific Signatures

The paper exposes cells to destabilized TTR variants and analyzes transcriptional and epigenetic responses to identify cell- and protein-specific signatures of amyloidogenic stress.

Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice

This study demonstrates the durable engraftment of PSC-derived lung epithelial cells into immunocompetent mice, showing long-term retention of both progenitor and differentiated cell phenotypes.

Multi-modal profiling of peripheral blood cells across the human lifespan reveals distinct immune cell signatures of aging and longevity

The paper analyzes immune cell changes in centenarians and younger individuals to identify aging and longevity signatures in peripheral blood cells.

Impact of cell culture on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells

This study compares the transcriptomes of primary, cultured, and iPSC-derived human alveolar type 2 cells to assess how culture affects their gene expression profiles and maturation states.

Modeling of Alpha-1 Antitrypsin Deficiency with Syngeneic Human iPSC-Hepatocytes Reveals Metabolic Dysregulation and Cellular Heterogeneity in PiMZ and PiZZ Hepatocytes

This study uses CRISPR-Cas9 to create syngeneic iPSC-derived hepatocytes with ZAAT heterozygosity, revealing metabolic dysregulation and cellular heterogeneity in MZ and ZZ cells.

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

Patient-specific iPSCs carrying an SFTPC mutation reveal the intrinsic alveolar epithelial dysfunction at the inception of interstitial lung disease

This study uses patient-derived iPSCs with an SFTPC mutation to model early alveolar epithelial dysfunction in interstitial lung disease, revealing proteostasis, metabolic, and inflammatory changes.

Multi-Modal Profiling of Human Fetal Liver-Derived Hematopoietic Stem Cells Reveals the Molecular Signature of Engraftment Potential

The paper profiles human fetal liver hematopoietic stem cells using multi-modal data to identify a molecular signature associated with engraftment potential.

Airway-associated macrophages in homeostasis and repair

The paper identifies airway-associated macrophage subpopulations and their roles in tracheal homeostasis and repair using single-cell RNA sequencing and other techniques.