Author

F. J. Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Microbiology· 2 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 7 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:metabolomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

C. N. Brocker· 2 shared D. Kim· 2 shared L. Sun· 2 shared S. Takahashi· 2 shared t. J. velenosi· 2 shared Y. Luo· 2 shared A. D. Patterson· 1 shared A. E. Finzi· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersPhysiology

C. N. Brocker

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

The American Journal of Pathology · Dec 1, 2023Peer-reviewedPathology

Changes in the Type 2 diabetes gut mycobiome associate with metformin treatment across populations

E. Van Syoc, M. P. Nixon, J. D. Silverman, Y. Luo, F. J. Gonzalez, I. Elbere, J. Klovins, A. D. Patterson, C. J. Rogers, E. Ganda

This study identifies metformin and T2D as factors influencing gut fungal communities across human populations.

bioRxiv · May 25, 2023 · PreprintMicrobiology

Amino acid transporter SLC7A5 regulates Paneth cell function to affect the intestinal inflammatory response

L. Bao, l. fu, y. su, z. chen, z. peng, L. Sun, F. J. Gonzalez, c. wu, h. zhang, b. shi, y.-b. shi

This study shows that SLC7A5 regulates Paneth cell function, affecting intestinal inflammation and cell proliferation through mTORC1 signaling.

bioRxiv · Jan 24, 2023 · PreprintImmunology

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Long non-coding RNA G23Rik attenuates fasting-induced lipid accumulation in the liver

D. Kim, B. Kim, C. N. Brocker, K. Karri, D. J. Waxman, F. J. Gonzalez

This study identifies G23Rik as a PPAR-regulated lncRNA that reduces hepatic lipid accumulation during fasting.

bioRxiv · Apr 11, 2022Physiology

Pharmacometabolomics reveals urinary diacetylspermine as a biomarker of doxorubicin effectiveness in triple negative breast cancer

T. J. Velenosi, K. W. Krausz, K. Hamada, T. Dorsey, S. Ambs, S. Takahashi, F. J. Gonzalez

bioRxiv · Jan 19, 2022Cancer Biology

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities

Y. Chen, L. Sun, I. Ullah, G. Beaudoin-Bussieres, S. P. Anand, A. P. Hederman, W. D. Tolbert, R. Sherburn, D. N. Nguyen, L. Marchitto, S. Ding, D. Wu, Y. Luo, S. Gottumukkala, S. Moran, , M. Pazgier

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

bioRxiv · Nov 24, 2021Microbiology

Dietary intake regulates the circulating inflammatory monocyte pool

S. Jordan, N. Tung, M. Casanova-Acebes, C. Chang, C. Cantoni, D. Zhang, T. H. Wirtz, S. Naik, S. A. Rose, C. N. Brocker, A. Gainullina, B. B. Maier, D. LeRoith, F. J. Gonzalez, F. Meissner, , M. Merad

This study shows that fasting reduces circulating pro-inflammatory monocytes and their metabolic activity, while preserving their emergency mobilization during acute inflammation.

bioRxiv · Mar 21, 2019Immunology