Cancer BiologybioRxiv
Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer
K. Balamurugan, S. Sehareen, S. Sharan…·E. Sterneck
This study identifies COX-2/GSK3β signaling as a mechanism maintaining E-cadherin adhesions in metastatic breast cancer, showing that targeting this pathway reduces metastasis and improves outcomes.
DOI 10.1172/jci.insight.156057