Author

A. J. Ewald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Cho· 1 shared A. Cimino-Matthews· 1 shared A. Desphande· 1 shared A. Hernandez· 1 shared A. J. Crawford· 1 shared B. R. Si· 1 shared C. Jang· 1 shared C. Wong· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperCancer Biology

A. Cho

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3 papers

Recent·Most cited

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

E. M. Grasset, A. Desphande, J. W. Lee, Y. Cho, S. M. Shin, E. M. Coyne, A. Hernandez, X. Yuan, A. Cimino-Matthews, A. J. Ewald, W. J. Ho

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

bioRxiv · Mar 15, 2024Cancer Biology

Serine synthesis pathway upregulated by E-cadherin is essential for the proliferation and metastasis of breast cancers

G. Lee, C. Wong, A. Cho, J. J. West, A. J. Crawford, G. C. Russo, B. R. Si, J. Kim, L. Hoffner, C. Jang, M. Jung, R. D. Leone, K. Konstantopoulos, A. J. Ewald, D. Wirtz, S. Jeong

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

bioRxiv · May 24, 2023 · PreprintCancer Biology

Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer

K. Balamurugan, S. Sehareen, S. Sharan, S. Krishnamurthy, W. Tang, L. McKennett, V. Padmanaba, K. T. Czarra, A. J. Ewald, S. Ambs, N. T. Ueno, D. K. Poria, E. Sterneck

This study identifies COX-2/GSK3β signaling as a mechanism maintaining E-cadherin adhesions in metastatic breast cancer, showing that targeting this pathway reduces metastasis and improves outcomes.

bioRxiv · Jan 18, 2022Cancer Biology