Author
S. Krishnamurthy
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 17 mutual co-author links9 papers
Recent·Most cited
TREX reveals proteins that bind to specific RNA regions in living cells
M. Dodel, G. Guiducci, M. Dermit, S. Krishnamurthy, L. Stojic, F. K. Mardakheh
TREX identifies RNA-binding proteins interacting with specific RNA regions in living cells, revealing novel interactions in 45S rRNA and U1 snRNA.
bioRxiv · Jun 30, 2023Cell Biology
Evolutionary adaptation of the folding pathway for secretability
D. Smets, A. Tsirigotaki, J. H. Smit, S. Krishnamurthy, A. Portaliou, A. Vorobieva, W. Vranken, S. Karamanou, A. Economou
This study identifies structural features that delay folding in secretory proteins, enabling their translocation, by comparing PpiA and PpiB.
bioRxiv · Apr 3, 2022 · PreprintBiochemistry
Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer
K. Balamurugan, S. Sehareen, S. Sharan, S. Krishnamurthy, W. Tang, L. McKennett, V. Padmanaba, K. T. Czarra, A. J. Ewald, S. Ambs, N. T. Ueno, D. K. Poria, E. Sterneck
This study identifies COX-2/GSK3β signaling as a mechanism maintaining E-cadherin adhesions in metastatic breast cancer, showing that targeting this pathway reduces metastasis and improves outcomes.
bioRxiv · Jan 18, 2022Cancer Biology
Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism
S. Krishnamurthy, M. F. Sardis, N. Eleftheriadis, K. E. Chatzi, J. H. Smit, K. Karathanou, G. Gouridis, A. G. Portaliou, A.-N. Bondar, S. Karamanou, A. Economou
The paper reveals how SecA's intrinsic dynamics and preprotein interactions enable translocation via a catch and release mechanism.
bioRxiv · Aug 31, 2021Biochemistry
Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion
E. Schlee Villodre, X. Hu, R. A. Larson, P. Finetti, K. Gomez, W. Balema, S. R. Stecklein, G. Santiago-Sanchez, S. Krishnamurthy, J. Song, X. Su, N. T. Ueno, D. Tripathy, S. Van Laere, F. Bertucci, , B. G. Debeb
This study shows that lipocalin 2 promotes inflammatory breast cancer aggressiveness and skin invasion by enhancing proliferation, migration, and metastasis.
bioRxiv · Mar 18, 2021Cancer Biology
Decorin, a novel negative modulator of E-cadherin in inflammatory breast cancer
X. Hu, E. Schlee Villodre, R. A. Larson, O. M. Rahal, X. Wang, Y. Gong, J. Song, S. Krishnamurthy, N. T. Ueno, D. Tripathy, W. A. Woodward, B. G. Debeb
This study identifies decorin as a negative regulator of E-cadherin in inflammatory breast cancer, showing it reduces migration, invasion, and metastasis by destabilizing E-cadherin and inhibiting EGFR/ERK signaling.
bioRxiv · Jul 7, 2020Cancer Biology
A genome-wide loss-of-function screen identifies Toxoplasma gondii genes that determine fitness in interferon gamma-activated murine macrophages
Y. Wang, L. O. Sangare, T. C. Paredes-Santos, S. Krishnamurthy, M. A. Hassan, A. M. Furuta, B. M. Markus, S. Lourido, J. P. J. Saeij
The paper uses a genome-wide CRISPR screen to identify Toxoplasma gondii genes critical for fitness in IFN-gamma-activated murine macrophages, with GRA45 shown to prevent effector aggregation and enhance parasite survival.
bioRxiv · Dec 6, 2019 · PreprintMicrobiology