A Region of UNC-89 (obscurin) Lying Between Two Protein Kinase Domains is a Highly Elastic Spring Required for Proper Sarcomere Assembly
H. Qadota, J. C. Moody, L. Lesanpezeshki, T. Moncrief, D. Kitzler, P. D. Bhat, S. A. Vanapalli, A. F. Oberhauser, G. M. Benian
This paper identifies a highly elastic interkinase region in UNC-89 essential for sarcomere assembly, showing that its deletion causes sarcomere disorganization and locomotion defects in C. elegans.
bioRxiv · Apr 3, 2020Cell Biology