Author

S. A. Vanapalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:C. elegans· 5 Research Focus:cell type annotation· 3 Research Focus:development & morphogenesis· 3 Assay:imaging· 2 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

L. Lesanpezeshki· 3 shared A. Gangadhar· 2 shared H. Qadota· 2 shared M. Driscoll· 2 shared N. J. Szewczyk· 2 shared A. Antebi· 1 shared A. F. Oberhauser· 1 shared C. M. Lacerda· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

L. Lesanpezeshki

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Author profile →

7 papers

Recent·Most cited

FHOD-1/profilin-mediated actin assembly protects sarcomeres against contraction-induced deformation in C. elegans

M. J. Kimmich, S. Sundaramurthy, M. A. Geary, L. Lesanpezeshki, C. V. Yingling, S. A. Vanapalli, R. S. Littlefield, D. Pruyne

This study shows FHOD-1 and profilin cooperate to stabilize sarcomere Z-lines in C. elegans by promoting actin assembly and preventing muscle deformation during contraction.

bioRxiv · Feb 29, 2024 · PreprintCell Biology

Inertial Focusing of Particles and Cells in the Microfluidic Labyrinth Device: Role of Sharp Turns

A. Gangadhar, S. A. VANAPALLI

This study investigates inertial focusing of particles and cells in a microfluidic labyrinth device with sharp turns, finding that turns improve cell separation but are less effective for rigid particles.

bioRxiv · Jun 2, 2022Bioengineering

Staining-Free, In-Flow Enumeration of Tumor Cells in Blood Using Digital Holographic Microscopy and Deep Learning

A. Gangadhar, H. Sari-Sarraf, S. A. VANAPALLI

This paper demonstrates a staining-free method for detecting tumor cells in blood using digital holographic microscopy and deep learning, achieving high accuracy and low false positive rates.

bioRxiv · May 1, 2022 · PreprintBioengineering

Investigating the correlation of muscle function tests and sarcomere organization in C. elegans

L. Lesanpezeshki, H. Qadota, M. Norouzi Darabad, K. Kashyap, C. M. Lacerda, N. J. Szewczyk, G. Benian, S. A. Vanapalli

This study investigates the relationship between muscle function and sarcomere organization in C. elegans using two assays, finding that mutants with sarcomere defects show reduced muscle strength and that combined assays improve phenotyping.

bioRxiv · Apr 13, 2021Physiology

Multi-environment phenotyping of C. elegans for robust evaluation of physical performance

J. E. Hewitt, R. Laranjeiro, M. Norouzi, R. Ellwood, A. Antebi, N. J. Szewczyk, M. Driscoll, S. A. Vanapalli

This study introduces a multi-environment phenotyping approach to assess physical performance in C. elegans and evaluates drug interventions in a muscular dystrophy model.

bioRxiv · Aug 17, 2020 · PreprintPhysiology

A Region of UNC-89 (obscurin) Lying Between Two Protein Kinase Domains is a Highly Elastic Spring Required for Proper Sarcomere Assembly

H. Qadota, J. C. Moody, L. Lesanpezeshki, T. Moncrief, D. Kitzler, P. D. Bhat, S. A. Vanapalli, A. F. Oberhauser, G. M. Benian

This paper identifies a highly elastic interkinase region in UNC-89 essential for sarcomere assembly, showing that its deletion causes sarcomere disorganization and locomotion defects in C. elegans.

bioRxiv · Apr 3, 2020Cell Biology

NemaLife: A structured microfluidic culture device optimized for aging studies in crawling C. elegans

M. Rahman, H. Edwards, N. Birze, R. Gabrilska, K. P. Rumbaugh, J. Blawzdziewicz, N. Szewczyk, M. Driscoll, S. A. Vanapalli

The paper introduces NemaLife, a microfluidic device for aging studies in C. elegans that allows crawling, prevents progeny contamination, and enables reagent addition, validated with longevity and healthspan analyses.

bioRxiv · Jun 19, 2019Bioengineering