Molecular basis for redox control by the human cystine/glutamate antiporter System xc-.
J. L. Parker, J. C. Deme, D. Kolokouris, G. Kuteyi, S. M. Lea, S. Newstead
The paper determines the cryo-EM structure of System xc- in apo and glutamate-bound states, revealing an allosteric mechanism for ligand discrimination and cystine transport.
bioRxiv · Aug 9, 2021Biochemistry