Author

J. L. Parker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:structural biology· 2 Research Focus:cell signaling & trafficking· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

S. Newstead· 3 shared P. Biggin· 2 shared A. Gerondopoulos· 1 shared D. Kolokouris· 1 shared F. A. Barr· 1 shared G. Kuteyi· 1 shared J. C. Deme· 1 shared P. Bräuer· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

S. Newstead

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Author profile →

3 papers

Recent·Most cited

The mechanism of mammalian proton-coupled peptide transporters

S. M. Lichtinger, J. L. Parker, S. Newstead, P. Biggin

This study uses molecular dynamics simulations to elucidate the conformational mechanism and proton-substrate coupling in mammalian POTs, revealing key structural differences and functional insights.

bioRxiv · Feb 4, 2024Biophysics

Molecular basis for redox control by the human cystine/glutamate antiporter System xc-.

J. L. Parker, J. C. Deme, D. Kolokouris, G. Kuteyi, S. M. Lea, S. Newstead

The paper determines the cryo-EM structure of System xc- in apo and glutamate-bound states, revealing an allosteric mechanism for ligand discrimination and cystine transport.

bioRxiv · Aug 9, 2021Biochemistry

A baton-relay mechanism for ER retrieval signal capture and proofreading by the KDEL receptor

A. Gerondopoulos, P. Bräuer, T. Sobajima, Z. Wu, J. L. Parker, P. Biggin, F. A. Barr, S. Newstead

The paper investigates the KDEL receptor's mechanism for capturing and proofreading ER retrieval signals, revealing a baton-relay mechanism and selective proofreading steps.

bioRxiv · Mar 21, 2021Cell Biology