Author

J. C. Deme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

S. M. Lea· 5 shared A. Hutchinson· 2 shared A. Seitova· 2 shared C. H. Arrowsmith· 2 shared P. Loppnau· 2 shared R. J. Harding· 2 shared A. Hunter· 1 shared A. J. R. Heck· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersBiochemistry

S. M. Lea

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Author profile →

5 papers

Recent·Most cited

Three small partner proteins facilitate the type VII-dependent secretion export of an antibacterial nuclease

Y. Yang, E. Boardman, J. C. Deme, F. Alcock, S. M. Lea, T. Palmer

The paper identifies three small proteins that facilitate the export of an antibacterial nuclease via the type VIIb secretion system in Staphylococcus aureus.

bioRxiv · Apr 1, 2023Microbiology

Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein

M. G. Alteen, J. C. Deme, C. P. Alvarez, P. Loppnau, A. Hutchinson, A. Seitova, R. Chandrasekaran, E. Silva Ramos, C. Secker, M. Alqazzaz, E. E. Wanker, S. M. Lea, C. H. Arrowsmith, R. J. Harding

This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.

bioRxiv · Nov 21, 2022Biochemistry

Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes

R. Hennell James, J. C. Deme, A. Hunter, B. C. Berks, S. M. Lea

The paper presents structures of the GldLM motor complex from multiple Bacteroidetes species, revealing conserved architecture and species-specific differences in the N-terminus of GldL.

bioRxiv · Jan 28, 2022 · PreprintBiochemistry

Molecular basis for redox control by the human cystine/glutamate antiporter System xc-.

J. L. Parker, J. C. Deme, D. Kolokouris, G. Kuteyi, S. M. Lea, S. Newstead

The paper determines the cryo-EM structure of System xc- in apo and glutamate-bound states, revealing an allosteric mechanism for ligand discrimination and cystine transport.

bioRxiv · Aug 9, 2021Biochemistry

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

R. J. Harding, J. C. Deme, J. F. Hevler, S. Tamara, A. Lemak, J. P. Cantle, M. M. Szewczyk, X. Zuo, P. Loppnau, A. Seitova, A. Hutchinson, L. Fan, M. Schapira, J. B. Carroll, A. J. R. Heck, , C. H. Arrowsmith

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

bioRxiv · Apr 2, 2021Biochemistry