S. M. Lea

An interbacterial lipase toxin with an unprecedented reverse domain arrangement defines a new class of type VII secretion system effector

The paper identifies a new class of T7SS effector, TslA, with a reverse domain arrangement and describes its secretion mechanism and functional properties.

Three small partner proteins facilitate the type VII-dependent secretion export of an antibacterial nuclease

The paper identifies three small proteins that facilitate the export of an antibacterial nuclease via the type VIIb secretion system in Staphylococcus aureus.

Expanding the Huntingtons disease research toolbox; validated huntingtin subdomain constructs for biochemical and structural investigation of the huntingtin protein

This paper develops validated HTT subdomain constructs for biochemical and structural studies of huntingtin protein interactions and function.

Structures of the Type IX Secretion/gliding motility motor from across the phylum Bacteroidetes

The paper presents structures of the GldLM motor complex from multiple Bacteroidetes species, revealing conserved architecture and species-specific differences in the N-terminus of GldL.

Molecular basis for redox control by the human cystine/glutamate antiporter System xc-.

The paper determines the cryo-EM structure of System xc- in apo and glutamate-bound states, revealing an allosteric mechanism for ligand discrimination and cystine transport.

Targeting properdin - Structure and function of a novel family of tick-derived complement inhibitors

This study identifies and characterizes a novel family of tick-derived complement inhibitors, CirpA, which bind to properdin and inhibit complement activation.

HAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1

This study reveals how HAP40 orchestrates HTT structure, affecting its interaction with polyglutamine-expanded exon 1, providing insights into Huntington's disease mechanisms.

Molecular structure of the intact bacterial flagellar basal body

The paper presents the molecular structure of the Salmonella flagellar basal body using cryo-electron microscopy, revealing how 173 protein molecules assemble into a complex spanning two membranes and a cell wall.

Nonameric structures of the cytoplasmic domain of FlhA and SctV in the context of the full-length protein

The paper determines the structure of the nonameric cytoplasmic domains of FlhA and SctV using cryo-EM, revealing a conserved interaction stabilizing the ring assembly.

Molecular basis for B. pertussis interference with complement, coagulation, fibrinolytic and contact activation systems: The cryo-EM structure of the Vag8-C1 inhibitor complex

The paper determines the cryo-EM structure of the Vag8-C1-INH complex, revealing how Vag8 disrupts C1-INH function by sequestering its Reactive Centre Loop.

Structures of the stator complex that drives rotation of the bacterial flagellum

The paper presents structures of stator complexes from multiple bacterial species, revealing an asymmetric A5B2 subunit assembly and its role in coupling ion flow to generate mechanical work.

Structure of a proton-powered molecular motor that drives protein transport and gliding motility

This study determines the structure of a proton-driven motor in Bacteroidetes bacteria and identifies key residues involved in its function.

A novel inhibitor of complement C5 provides structural insights into activation

The paper identifies a novel inhibitor from tick saliva, determines its structure bound to complement C5, and reveals a new mechanism of C5 inhibition.

The structure of an injectisome export gate demonstratesconservation of architecture in the core export gatebetween flagellar and virulence type three secretionsystems

The paper presents the structure of a T3SS export gate complex from Shigella at 3.5 Å resolution, confirming structural conservation with the flagellar system.