Pro-IL-18 secreted by keratinocytes detects the group A streptococcal protease SpeB
A. F. Johnson, J. S. Sands, K. Trivedi, R. Russell, D. L. LaRock, C. N. LaRock
The paper shows keratinocytes secrete inert pro-IL-18 which is activated by GAS protease SpeB, triggering an inflammatory response against GAS.
bioRxiv · Aug 22, 2021 · PreprintMicrobiology